منابع مشابه
Microbial DNA regulates intestinal homeostasis via the AIM2 inflammasome
Absent in melanoma 2 (AIM2) is a cytosolic DNA sensor which upon activation assembles a multiprotein complex called the inflammasome. Previous studies have shown that several inflammasome-forming pattern recognition receptors exhibit a protective function against inflammatory bowel disease and colorectal cancer. However, the role of AIM2 in sensing intestinal microbial DNA and regulating inflam...
متن کاملInflammasomes as microbial sensors.
Members of the Nod-like receptor family and the adaptor ASC assemble into multiprotein platforms, termed inflammasomes, to mediate the activation of caspase-1 and subsequent secretion of IL-1beta and IL-18. Recent studies have identified microbial and endogenous molecules as well as possible mechanisms involved in inflammasome activation.
متن کاملAncient and Recent Selective Pressures Shaped Genetic Diversity at AIM2-Like Nucleic Acid Sensors
AIM2-like receptors (ALRs) are a family of nucleic acid sensors essential for innate immune responses against viruses and bacteria. We performed an evolutionary analysis of ALR genes (MNDA, PYHIN1, IFI16, and AIM2) by analyzing inter- and intraspecies diversity. Maximum-likelihood analyses indicated that IFI16 and AIM2 evolved adaptively in primates, with branch-specific selection at the catarr...
متن کاملAIM2: Improved implementation of AIM
We present AIM2-F , an improved implementation of AIM-F [4] algorithm for mining frequent itemsets. Past studies have proposed various algorithms and techniques for improving the efficiency of the mining task. We have presented AIM-F at FIMI’03, a combination of some techniques into an algorithm which utilize those techniques dynamically according to the input dataset. The algorithm main featur...
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cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2010
ISSN: 1931-3128
DOI: 10.1016/j.chom.2010.05.002